총 166페이지

H5N1HPAIoutbreaksbetween2003to2012worldwide
Mostmajorwildbirddieoffeventshavetookplacein2005and2006.Sincethen,therehave
beennolargescalewildbirdmortalityevents
Conclusions
? At?least?6?species?(include?predator?such?as?crows?for?eating?died?birds)?of?
wildbirdshavebeenshowntobesusceptibletoinfection
? All?previous?H5N1?isolates?were?obtained?from?tissue?samples?of?died?or?ill?
wild?birds?and?the?last?case?reported?in?wild?bird?population?ill?whooper?
swansinApr2011
? Interestingly,?more?than?2?years?later?in?2013,?first?isolates?obtained?from?
fecal?samples?and?phylogenetic?analysis?revealed?that?the?HA?genes?of?the?
isolateswerealsoclassifiedintoclade2321andhomologywereclosely
related?(99%)?with?recent?(2009/2010)?Mongolian?HPAI/H5N1?isolates?that?
recently?circulating?in?Eastern?Asia
? AlsoGeneticcharacterizationoftheHAgenerevealedthecleavagesiteof
the?isolates?(PQRERRRKRGLF)?consistent?with?HPAI?viruses.
? However,?we?did?not?find?any?birds?clinically?ill?or?dead?in?the?sampling?sites.?
Th t
lt
t 2321 l d HPAI/H5N1i till i l ti i
ildbi d
(whooper?swan)?population?without?any?clinically?sing?or?mortality.?
? 2013?isolation?suggesting?wild?birds?have?become?less?susceptible?or?
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