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과 제 명 동물원 및 방사사육 조류에서의 조류인플루엔자 감염실태 조사
논
문
Genetic and biological characteristics of recent Korean isolates of avian
발표제목
게
influenza virus subtype H9N2
재
Madhav Prasad Acharya, Hyuk-Joon Kwon, Il-Hwan Kim, Youn-Jeong Lee,
발 표 자
?
비
Jae-Hong Kim
S
수록잡지 대한수의학회지 52(4) : 223-230
발표시기
2012년 12월
C
I
?
Abstract :
The worldwide distribution and continuing genetic mutation of avian influenza
virus(AIV) has been posed a great threat to human and animal health. A comparison
of 3 isolates of AIV H9N2, A/chicken/Korea/KBNP-0028/00(H9N2) (KBNP-0028),
A/chicken/Korea/SNU8011/08(H9N2) (SNU 8011) and an inactivated oil vaccine strain
A/chicken/Korea/01310/01(H9N2) (01310), was performed. The former 2 AIVs were
isolated from field cases before and after the application of an inactivated H9N2
vaccine in 2007, respectively. The antigenic relationship, viral shedding, tissue tropism
and genetic analysis were examined. The comparison of virus shedding from the
cloaca and the oropharynx revealed that both isolates were more frequently isolated
from the upper respiratory tract(90~100%) 1 day post inoculation(DPI) compared with
isolation 5 DPI from gastrointestinal tracts(10~60%). Moreover, the isolate KBNP-0028
were recovered from all organs including bone marrow, brain and kidneys, indicating
higher ability for broad tissue dissemination than that of SNU 8011. KBNP-0028
replicated earlier than other strains and with a higher titer than SNU 8011. In
full-length nucleotide sequences of the NA gene and a partial sequence of the HA
gene of SNU 8011, we found that there might be significant changes in tissue tropism,
virus replication and genetic mutation in AIV H9N2 isolates.
883
논
문
Genetic and biological characteristics of recent Korean isolates of avian
발표제목
게
influenza virus subtype H9N2
재
Madhav Prasad Acharya, Hyuk-Joon Kwon, Il-Hwan Kim, Youn-Jeong Lee,
발 표 자
?
비
Jae-Hong Kim
S
수록잡지 대한수의학회지 52(4) : 223-230
발표시기
2012년 12월
C
I
?
Abstract :
The worldwide distribution and continuing genetic mutation of avian influenza
virus(AIV) has been posed a great threat to human and animal health. A comparison
of 3 isolates of AIV H9N2, A/chicken/Korea/KBNP-0028/00(H9N2) (KBNP-0028),
A/chicken/Korea/SNU8011/08(H9N2) (SNU 8011) and an inactivated oil vaccine strain
A/chicken/Korea/01310/01(H9N2) (01310), was performed. The former 2 AIVs were
isolated from field cases before and after the application of an inactivated H9N2
vaccine in 2007, respectively. The antigenic relationship, viral shedding, tissue tropism
and genetic analysis were examined. The comparison of virus shedding from the
cloaca and the oropharynx revealed that both isolates were more frequently isolated
from the upper respiratory tract(90~100%) 1 day post inoculation(DPI) compared with
isolation 5 DPI from gastrointestinal tracts(10~60%). Moreover, the isolate KBNP-0028
were recovered from all organs including bone marrow, brain and kidneys, indicating
higher ability for broad tissue dissemination than that of SNU 8011. KBNP-0028
replicated earlier than other strains and with a higher titer than SNU 8011. In
full-length nucleotide sequences of the NA gene and a partial sequence of the HA
gene of SNU 8011, we found that there might be significant changes in tissue tropism,
virus replication and genetic mutation in AIV H9N2 isolates.
883
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