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Figure 11. DNA methylation of hepatocyte-specific genes by AFB1 on the hepatocyte
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Figure 11. DNA methylation of hepatocyte-specific genes by AFB1 on the hepatocyte
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development. Promoter regions of HNF1A (-162 to +24), HNF4A (-298 to +55)
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and Albumin (-14 to +185) were analyzed at day 8, 12 and 15 of Stage III (a).
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Total DNA methylation of the promoter regions was gradually demethylated in
no treatment of AFB1 (DMSO) while the regions were still hypermethylated in
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the treatment of non-cytotoxic concentrations (b).
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