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Figure 12. DNA methylation of hepatocyte-specific genes by AFB1 in primary hepatocytes.
3.1 and 6.3 uM of AFB1 decreased cell viability in primary hepatocytes after 48h
treatment (a). Promoter of HNF1A (b, c) and Albumin (f, g) was not affected by
AFB1 (b, c). However, total DNA methylation was significantly increased by
AFB1 in the region of HNF4A (d, e).
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Figure 12. DNA methylation of hepatocyte-specific genes by AFB1 in primary hepatocytes.
3.1 and 6.3 uM of AFB1 decreased cell viability in primary hepatocytes after 48h
treatment (a). Promoter of HNF1A (b, c) and Albumin (f, g) was not affected by
AFB1 (b, c). However, total DNA methylation was significantly increased by
AFB1 in the region of HNF4A (d, e).
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