총 44페이지

Interferon-
promotes abortion due to
Brucella infection in pregnant mice
Suk Kim
College of Veterinary Medicine, Gyeongsang National University, Jinju,
Gyeongnam, Korea.
The mechanisms of abortion induced by bacterial infection are largely
Brucella
unknown. In the present study, we investigated abortion induced by
abortus, a causative agent of brucellosis and facultative intracellular pathogen,
in a mouse model.
High rates of abortion were observed for bacterial infection on day 4.5 of
gestation, but not for other days. Regardless of whether fetuses were aborted
or stayed alive, the transmission of bacteria into the fetus and bacterial
replication in the placenta were observed. There was a higher degree of
bacterial colonization in the placenta than in other organs and many bacteria
were
detected
trophoblast
giant
cells
placenta.
Intracellular
virB4 mutant and attenuated vaccine strain S19 did not
growth-defective
induce abortion. In the case of abortion, around day 7.5 of gestation (period of
placental development), transient induction of IFN-
production was observed
for infection by the wild type strain, but not by the
virB4 mutant and S19.
Neutralization of IFN- , whose production was induced by infection with
abortus, served to prevent abortion.
B. abortus infection is a
These results indicate that abortion induced by
result
transient
IFN-
production
during
period
placental
development.
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