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131
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37. Immunobiology of the Tomatine adjuvant. Vaccine 22 (2004) 2380-2384.
38. Evaluation of novel aggregate structures as adjuvants: composition, toxicity
studies and humoral responses. Vaccine 17 (1999) 715-730.
39. The potential use of tomato lectin for oral drug delivery: 4. Immunological
consequences. International Journal of Pharmaceutics 120 (1995) 247-254.
40. Antibacterial, antifungal, and antiviral activities of the lipophylic extracts of
Pistacia vera. Microbiological Research 160 (2005) 159-164.
41. The in vitro antiviral activity of an aliphatic nitro compound from
Heteropteris
aphrodisiaca. Microbiological Research 163 (2008) 136-139.
42. RLJ-NE-299A: A new plant based vaccine adjuvant. Vaccine 25 (2007)
2706-2715.
43. Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from
Picrorhiza
kurroa. International Immunopharmacology 6 (2006) 1543-1549
44. Anti-inflammatory activity of Indian black tea(Sikkim variety). Pharmacology
Research 51 (2005) 169-175.
9. À̳¢(Lichen) ¹× Á¶·ù(Algae)
À̳¢·ù¿¡¼ ÃßÃâÇÑ ´Ù´ç·ù°¡ ¼÷ÁÖ¹æ¾îÀÇ Áß¿äÇÑ ¿ªÇÒÀ» ÇÏ´Â ´ë½Ä¼¼Æ÷ÀÇ È°¼ºÀ» Áõ°½ÃŲ
´Ù°í ¾Ë·ÁÁ® ÀÖ´Ù. ÀÌ°ÍÀº ¹ö¼¸À¯·¡ º£Å¸-±¸·çÄ(¥â-glucan)°ú À¯»çÇϸ鼵µ ´Ù¸¥ ¸é¿ªÁõ°
Cetraria islandica) À¯·¡ ¶óÀÌÄɳ(lichenan)°ú ¾Æ
È°¼ºÀÌ ÀÖ´Â ´Ù´ç·ùÀÎ, ¾ÆÀ̽½¶õµå À̳¢(
À̼ҶóÀÌÄɳ(isolichenan), À̳¢·ù(
Thamnolia subuliformis) À¯·¡ Ž³ë¶õ(thamnolan) µîÀÌ
ÀÖÀ¸¸ç, 5°èÅë 9Á¾ÀÇ Á¶·ù¿¡¼ ºÐ¸®ÇÑ ´Ù´ç·ùµµ ´ë½Ä¼¼Æ÷ÀÇ Å½½Ä°ú ºÐºñÈ°¼º ±×¸®°í ¹ÝÀÀ¼º
»ê¼Ò·ù(reactive oxygen species, ROS), »êÈÁú¼Ò(NO), »çÀÌÅäÄ«ÀÎ(TNF-¥á, IL-1, IL-6)
»ý¼ºÀ» Áõ°½ÃŲ´Ù. ¶ÇÇÑ ³²Á¶·ùÀÎ ½ºÇǷ縮³ª ÇÁ¶óÅٽýº(
Spirulina platensis) À¯·¡ ´Ù´ç·ù°¡
Ç×Á¾¾ç ¹× Ç×ÀüÀÌ È°¼ºÀ» ³ªÅ¸³½´Ù.
Ç¥ 3. ÇØÁ¶·ù ´Ù´ç·ù(Algal polysaccharides)ÀÇ ´ë½Ä¼¼Æ÷ È°¼º¿¡ ¹ÌÄ¡´Â ¿µÇâ
ÇØÁ¶·ù ´Ù´ç·ù ´ë½Ä¼¼Æ÷¿¡ ¹ÌÄ¡´Â ¿µÇâ
Aphanizomenon flos Immunon(>10,000kDa) MO activation/IL-1¥â/
aquae(Nostocaceae) TNF-¥á message
Chlorella pyrenoidosa Immurella(>10,000kDa) MO activation/IL-1¥â/
(Chlorellaceae) TNF-¥á message
Cladosiphon okamuranus Fucoidan TNF-¥á/ROS
ToKida(Chordariaceae)
Euglena gracilis Paramylo<¥â-(1-3)-D- IL-1, IL-6
(Euglenaceae) glucan)>
Gracilaria verrucosa GWS-E(enzyme- Phagocytosis/ROS
(Gracilariaceae) degraded PS) (oral, I.P)
Hizikia fusiformis HPS-1(2000kDa), MO suppression of EL-4
. ½Ä ¹°
37. Immunobiology of the Tomatine adjuvant. Vaccine 22 (2004) 2380-2384.
38. Evaluation of novel aggregate structures as adjuvants: composition, toxicity
studies and humoral responses. Vaccine 17 (1999) 715-730.
39. The potential use of tomato lectin for oral drug delivery: 4. Immunological
consequences. International Journal of Pharmaceutics 120 (1995) 247-254.
40. Antibacterial, antifungal, and antiviral activities of the lipophylic extracts of
Pistacia vera. Microbiological Research 160 (2005) 159-164.
41. The in vitro antiviral activity of an aliphatic nitro compound from
Heteropteris
aphrodisiaca. Microbiological Research 163 (2008) 136-139.
42. RLJ-NE-299A: A new plant based vaccine adjuvant. Vaccine 25 (2007)
2706-2715.
43. Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from
Picrorhiza
kurroa. International Immunopharmacology 6 (2006) 1543-1549
44. Anti-inflammatory activity of Indian black tea(Sikkim variety). Pharmacology
Research 51 (2005) 169-175.
9. À̳¢(Lichen) ¹× Á¶·ù(Algae)
À̳¢·ù¿¡¼ ÃßÃâÇÑ ´Ù´ç·ù°¡ ¼÷ÁÖ¹æ¾îÀÇ Áß¿äÇÑ ¿ªÇÒÀ» ÇÏ´Â ´ë½Ä¼¼Æ÷ÀÇ È°¼ºÀ» Áõ°½ÃŲ
´Ù°í ¾Ë·ÁÁ® ÀÖ´Ù. ÀÌ°ÍÀº ¹ö¼¸À¯·¡ º£Å¸-±¸·çÄ(¥â-glucan)°ú À¯»çÇϸ鼵µ ´Ù¸¥ ¸é¿ªÁõ°
Cetraria islandica) À¯·¡ ¶óÀÌÄɳ(lichenan)°ú ¾Æ
È°¼ºÀÌ ÀÖ´Â ´Ù´ç·ùÀÎ, ¾ÆÀ̽½¶õµå À̳¢(
À̼ҶóÀÌÄɳ(isolichenan), À̳¢·ù(
Thamnolia subuliformis) À¯·¡ Ž³ë¶õ(thamnolan) µîÀÌ
ÀÖÀ¸¸ç, 5°èÅë 9Á¾ÀÇ Á¶·ù¿¡¼ ºÐ¸®ÇÑ ´Ù´ç·ùµµ ´ë½Ä¼¼Æ÷ÀÇ Å½½Ä°ú ºÐºñÈ°¼º ±×¸®°í ¹ÝÀÀ¼º
»ê¼Ò·ù(reactive oxygen species, ROS), »êÈÁú¼Ò(NO), »çÀÌÅäÄ«ÀÎ(TNF-¥á, IL-1, IL-6)
»ý¼ºÀ» Áõ°½ÃŲ´Ù. ¶ÇÇÑ ³²Á¶·ùÀÎ ½ºÇǷ縮³ª ÇÁ¶óÅٽýº(
Spirulina platensis) À¯·¡ ´Ù´ç·ù°¡
Ç×Á¾¾ç ¹× Ç×ÀüÀÌ È°¼ºÀ» ³ªÅ¸³½´Ù.
Ç¥ 3. ÇØÁ¶·ù ´Ù´ç·ù(Algal polysaccharides)ÀÇ ´ë½Ä¼¼Æ÷ È°¼º¿¡ ¹ÌÄ¡´Â ¿µÇâ
ÇØÁ¶·ù ´Ù´ç·ù ´ë½Ä¼¼Æ÷¿¡ ¹ÌÄ¡´Â ¿µÇâ
Aphanizomenon flos Immunon(>10,000kDa) MO activation/IL-1¥â/
aquae(Nostocaceae) TNF-¥á message
Chlorella pyrenoidosa Immurella(>10,000kDa) MO activation/IL-1¥â/
(Chlorellaceae) TNF-¥á message
Cladosiphon okamuranus Fucoidan TNF-¥á/ROS
ToKida(Chordariaceae)
Euglena gracilis Paramylo<¥â-(1-3)-D- IL-1, IL-6
(Euglenaceae) glucan)>
Gracilaria verrucosa GWS-E(enzyme- Phagocytosis/ROS
(Gracilariaceae) degraded PS) (oral, I.P)
Hizikia fusiformis HPS-1(2000kDa), MO suppression of EL-4
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