총 42페이지

베트남-한국간ODA사업관련소결핵및요네병진단교육
? CattleBCG
? Remains the best candidate in the short to
mediumterm
? Inexperimentalchallengemodel(AHVLA)
80vaccinatedcattlevs64controlcattle
?
? Fivedaysold~9monthsold
? Challenged between 3 months and 12 months
aftervaccination
? Novisiblelesion:29of80(V),2of64(C)
? Infieldtrials(Ethiopia)
? 13vaccinatedcattlevs14controlcattle
? Fivedaysold~9monthsold
? Challenged between 25 and 96 days after
vaccination
? Novisiblelesion:9of13(V),4of14(C)
? CattleBCG
? Divatest(Differentiateinfectedfromvaccinated)
? ConventionalskintestandIFN-rtest->can’t
differentiatebetweenvaccinatedandinfected
? DIVAtestusingpeptideantigen
ESAT6,CFP10(deletionduringattenuation)
+Rv3615c?IFN-r
Cocktailagforskintest
? Cattle BCG in filed trials is not yet possible in the
EU ? no direct evidence of reduced transmission
ofTBtoandbetweencattle
? Researchisunderway
? Candidate used in combination with BCG ?enhanced
protectionanddurationofimmunity
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