총 1147페이지
1075페이지 본문시작
Ⅷ. 영문초록
Risk assessment and scoring for veterinary drugs resided in
Title
livestock products
Researcher
Sang-Hee Jeong, Hyun-Ok Ku, Joon-Hyoung, Cho et al
- Abstract -
Veterinary drugs including antibiotics, antihelminths, growth hormones and
etc. are inevitably used for growth promotion and disease control of
livestock animals. However, concerns on the safety of livestock products
and prevalence of antimicrobial resistance have been increased according
to the increased amount of use of veterinary drugs. The current study
was performed to develop risk assessment procedure fitting to residual
veterinary drugs in livestock products and to rank the risk priority for
risk management. We assessed the risk of 269 veterinary drugs that are
authorized for use and have potential impact on human health according to
the risk assessment steps as hazard identification, hazard characterization,
exposure assessment and risk characterization. All scientific information
for risk assessment were compiled and classified into direct and indirect
hazardous factors, exposure factors and reference factors. The data on
toxicity (T), antimicrobial resistance (AR), the impact on human intestinal
microflora, regulatory concerns for prohibition, acceptable daily intake,
maximum residue limit (MRL) and residue violation rate for recent 5
years were allocated into hazardous factors and data on withdrawal period
(WP), production quantity of each veterinary drug for five years (PQ) and
food consumption amount were considered as exposure factors. The limit
of information on residue violation rate (LI) wasreferred as reference
factors. All factors were ranked into 0 to 5 and risk of each drug was
calculated according to the equation drawn by optimal weighing on
toxicity, MRL and withdrawal period. The equation for risk scoring was:
{residue
violation
rate
(or
estimated
risk:
0.16667
(3*MRL+2*WP+PQ))}×{AR+3*T}/4×{1+0.06667(LI-1)}.
Among
the
269 veterinary drugs assessed, furazolidon was the highest risky residual
drug scored as 25.33 and followed by dimetridazole, carbadox, hygromycin
B, avoparcin, olaquindox, metronidazole, chloramphenicl and enrofloxacin in
order. Diaveridine, fenitothion, fluvalinate, PST and didecyldimethyl
ammonium HCl were allocated into the lowest risk grade. The highly
ranked veterinary drugs in risk priority were assumed to have potent
public health impact by ingestion of the drugs resided in animal origin
food and should be controlled intensively for the prevention of residue in
food
Risk assessment, Risk scoring, Veterinary drugs, Livestock
Keyword
products, Food safety
- 1091 -
Risk assessment and scoring for veterinary drugs resided in
Title
livestock products
Researcher
Sang-Hee Jeong, Hyun-Ok Ku, Joon-Hyoung, Cho et al
- Abstract -
Veterinary drugs including antibiotics, antihelminths, growth hormones and
etc. are inevitably used for growth promotion and disease control of
livestock animals. However, concerns on the safety of livestock products
and prevalence of antimicrobial resistance have been increased according
to the increased amount of use of veterinary drugs. The current study
was performed to develop risk assessment procedure fitting to residual
veterinary drugs in livestock products and to rank the risk priority for
risk management. We assessed the risk of 269 veterinary drugs that are
authorized for use and have potential impact on human health according to
the risk assessment steps as hazard identification, hazard characterization,
exposure assessment and risk characterization. All scientific information
for risk assessment were compiled and classified into direct and indirect
hazardous factors, exposure factors and reference factors. The data on
toxicity (T), antimicrobial resistance (AR), the impact on human intestinal
microflora, regulatory concerns for prohibition, acceptable daily intake,
maximum residue limit (MRL) and residue violation rate for recent 5
years were allocated into hazardous factors and data on withdrawal period
(WP), production quantity of each veterinary drug for five years (PQ) and
food consumption amount were considered as exposure factors. The limit
of information on residue violation rate (LI) wasreferred as reference
factors. All factors were ranked into 0 to 5 and risk of each drug was
calculated according to the equation drawn by optimal weighing on
toxicity, MRL and withdrawal period. The equation for risk scoring was:
{residue
violation
rate
(or
estimated
risk:
0.16667
(3*MRL+2*WP+PQ))}×{AR+3*T}/4×{1+0.06667(LI-1)}.
Among
the
269 veterinary drugs assessed, furazolidon was the highest risky residual
drug scored as 25.33 and followed by dimetridazole, carbadox, hygromycin
B, avoparcin, olaquindox, metronidazole, chloramphenicl and enrofloxacin in
order. Diaveridine, fenitothion, fluvalinate, PST and didecyldimethyl
ammonium HCl were allocated into the lowest risk grade. The highly
ranked veterinary drugs in risk priority were assumed to have potent
public health impact by ingestion of the drugs resided in animal origin
food and should be controlled intensively for the prevention of residue in
food
Risk assessment, Risk scoring, Veterinary drugs, Livestock
Keyword
products, Food safety
- 1091 -
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