총 1147페이지
1076페이지 본문시작
Risk assessment and scoring for veterinary drugs resided in
Title
livestock products
Researcher
Sang-Hee Jeong, Jeong-Woo Kang, Joon-Hyoung, Cho et al
- Abstract -
Pesticides are chemical substance, biological agent (such as a virus or
bacteria), antimicrobial, disinfectant or device used against pests including
insects,
plant
pathogens,
nematodes
(roundworms),
especially
in
agricultural area. There are limited number of pesticides administered
directly to livestock animals but large number of pesticides can be
exposed to animals via breathing spread particles of pesticides or feeding
contaminated grass or drink. Concerns on the safety of livestock products
have been increased according to the increased amount of use of
pesticides. This study was performed to score the risk priority of all
kinds of pesticides that can be resided or contaminated in livestock
products based on risk assessment. All kinds of information on toxicity,
accumulation and human or animal exposure wall compiled via EPA,
Toxnet, JMPR, CODEX and etc. To develop risk assessment procedure
fitting to residual pesticides in livestock products and to rank the risk
priority for risk management, we assessed the risk of 942 pesticides that
are approved for use and have potential impact on human health according
to the procedures of hazard identification, hazard characterization,
exposure assessment and risk characterization based on the all compiled
data. 942 pesticides were selected as candidates that can be resided in
livestock products and induce adverse effects on human health and
classified into 23 categories according to their chemical properties. All
scientific information for risk assessment of the selected pesticides were
compiled and classified into direct and indirect hazardous factors, exposure
factors and reference factors. The data on toxicity (T), regulatory
concerns for prohibition (RP), residual risk (RR, TMDI/ADI), maximum
residue limit (MRL) and residue violation rate for recent 5 years (RV)
were allocated into hazardous factors and data on withdrawal period (WP),
production quantity of each pesticide for 5 years (PQ) and accumulation
ratio (AR) were categorized into exposure factors. The limit of
information on residue violation rate (LI) was referred to reference
factors. All factors were ranked into 0 to 5 and risk of each chemicalwas
calculated according to the equation drawn by optimal weighing on
toxicity, MRL and withdrawal period.
The equation for risk scoring was: [residue violation rate or estimated
risk: (3×MRL+2×RR+2×WP+PQ)+(AR+2×RP+3×T)/2]×{1+0.06667×
(LI-1)}. Among the 942 pesticides assessed, dimethoate was the highest
risky residual pesticide scored as 53.4 and followed by methidathion,
profenofos, parathion-methyl, amitraz, dicofol, and fenamiphos in order.
Uniconazole, validamycin, metopren, and pyrimiphos-methylwere allocated
into the lowest risk grade. The model developed by the present study for
the determination of risk priority of pesticides resided in livestock
products may provide the basis for the decision of risk management. The
highly ranked pesticides in risk priority are assumed to have potent public
health impact by ingestion of animal originated food and should be
controlled intensively for the prevention of residue in food in risk
management.
Risk
assessment,
Risk
scoring,
Pesticides,
Livestock
Keyword
products, Food safety
- 1092 -
Title
livestock products
Researcher
Sang-Hee Jeong, Jeong-Woo Kang, Joon-Hyoung, Cho et al
- Abstract -
Pesticides are chemical substance, biological agent (such as a virus or
bacteria), antimicrobial, disinfectant or device used against pests including
insects,
plant
pathogens,
nematodes
(roundworms),
especially
in
agricultural area. There are limited number of pesticides administered
directly to livestock animals but large number of pesticides can be
exposed to animals via breathing spread particles of pesticides or feeding
contaminated grass or drink. Concerns on the safety of livestock products
have been increased according to the increased amount of use of
pesticides. This study was performed to score the risk priority of all
kinds of pesticides that can be resided or contaminated in livestock
products based on risk assessment. All kinds of information on toxicity,
accumulation and human or animal exposure wall compiled via EPA,
Toxnet, JMPR, CODEX and etc. To develop risk assessment procedure
fitting to residual pesticides in livestock products and to rank the risk
priority for risk management, we assessed the risk of 942 pesticides that
are approved for use and have potential impact on human health according
to the procedures of hazard identification, hazard characterization,
exposure assessment and risk characterization based on the all compiled
data. 942 pesticides were selected as candidates that can be resided in
livestock products and induce adverse effects on human health and
classified into 23 categories according to their chemical properties. All
scientific information for risk assessment of the selected pesticides were
compiled and classified into direct and indirect hazardous factors, exposure
factors and reference factors. The data on toxicity (T), regulatory
concerns for prohibition (RP), residual risk (RR, TMDI/ADI), maximum
residue limit (MRL) and residue violation rate for recent 5 years (RV)
were allocated into hazardous factors and data on withdrawal period (WP),
production quantity of each pesticide for 5 years (PQ) and accumulation
ratio (AR) were categorized into exposure factors. The limit of
information on residue violation rate (LI) was referred to reference
factors. All factors were ranked into 0 to 5 and risk of each chemicalwas
calculated according to the equation drawn by optimal weighing on
toxicity, MRL and withdrawal period.
The equation for risk scoring was: [residue violation rate or estimated
risk: (3×MRL+2×RR+2×WP+PQ)+(AR+2×RP+3×T)/2]×{1+0.06667×
(LI-1)}. Among the 942 pesticides assessed, dimethoate was the highest
risky residual pesticide scored as 53.4 and followed by methidathion,
profenofos, parathion-methyl, amitraz, dicofol, and fenamiphos in order.
Uniconazole, validamycin, metopren, and pyrimiphos-methylwere allocated
into the lowest risk grade. The model developed by the present study for
the determination of risk priority of pesticides resided in livestock
products may provide the basis for the decision of risk management. The
highly ranked pesticides in risk priority are assumed to have potent public
health impact by ingestion of animal originated food and should be
controlled intensively for the prevention of residue in food in risk
management.
Risk
assessment,
Risk
scoring,
Pesticides,
Livestock
Keyword
products, Food safety
- 1092 -
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