ÃÑ 4558ÆäÀÌÁö

915ÆäÀÌÁö º»¹®½ÃÀÛ

³ó¸²Ãà»ê°Ë¿ª°Ë»ç±â¼ú°³¹ß»ç¾÷ 2015 ¿¬±¸º¸°í¼­
Figure 12. DNA methylation of hepatocyte-specific genes by AFB1 in primary hepatocytes.
3.1 and 6.3 uM of AFB1 decreased cell viability in primary hepatocytes after 48h
treatment (a). Promoter of HNF1A (b, c) and Albumin (f, g) was not affected by
AFB1 (b, c). However, total DNA methylation was significantly increased by
AFB1 in the region of HNF4A (d, e).
914
³ó¸²Ãà»ê°Ë¿ªº»ºÎ

915ÆäÀÌÁö º»¹®³¡



ÇöÀç Æ÷Ä¿½ºÀÇ ¾Æ·¡³»¿ëµéÀº µ¿ÀÏÇÑ ÄÁÅÙÃ÷¸¦ °¡Áö°í ÆäÀÌÁö³Ñ±è È¿°ú¹× ½Ã°¢Àû È¿°ú¸¦ Á¦°øÇÏ´Â ÆäÀÌÁöÀ̹ǷΠ½ºÅ©¸°¸®´õ »ç¿ëÀÚ´Â ¿©±â±îÁö¸¸ ³¶µ¶ÇϽðí À§ÀÇ ÆäÀÌÁöÀ̵¿ ¸µÅ©¸¦ »ç¿ëÇÏ¿© ´ÙÀ½ÆäÀÌÁö·Î À̵¿ÇϽñ⠹ٶø´Ï´Ù.
»ó´Ü¸Þ´º ¹Ù·Î°¡±â ´ÜÃàÅ°¾È³» : ÀÌÀüÆäÀÌÁö´Â ÁÂÃø¹æÇâÅ°, ´ÙÀ½ÆäÀÌÁö´Â ¿ìÃø¹æÇâÅ°, ùÆäÀÌÁö´Â »ó´Ü¹æÇâÅ°, ¸¶Áö¸·ÆäÀÌÁö´Â ÇϴܹæÇâÅ°, ÁÂÃøÈ®´ëÃà¼Ò´Â insertÅ°, ¿ìÃøÈ®´ëÃà¼Ò´Â deleteÅ°